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roxS [2017-03-30 15:17:27]
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roxS [2017-03-30 15:17:27]

small RNA, controls expression of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI] and [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD]
function
control of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI] and [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD] expression
product
trans-acting regulatory RNA
essential
no
synonyms
rsaE

Genomic Context

      

Expression and Regulation

Operons

genes
[gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]

description

  • [pubmed|22383849]

    • regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: transcriptional activation, [pubmed|22383849], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]
  • [protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: repression, [pubmed|28436820], in [regulon|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex regulon]

    • regulation

  • induced by nitric oxide (NO) ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]) [pubmed|22383849]
  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: transcriptional activation [pubmed|22383849]
  • [protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: transcriptional repression [pubmed|28436820]

    • additional information

  • the [gene|search|roxS ]RNA is degraded by the joined activities of RNase Y (initial endonucleolytic cleavage) and RNase J1 (processive degradation) [pubmed|22383849]
  • the [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|search|ppnKB ]and [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|search|sucC ]RNA duplexes form a cleavage site for RNase III [pubmed|22383849]
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    regulation
    [
    interaction

    the RNA

    basic information/ Evolution

  • hybridizes to [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI] and [gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD] mRNAs to inhibit their translation and to destabilize them [pubmed|25643072]

    • bioMaterials

    mutant

  • available in Ciaran Condon's lab [pubmed|25643072]

    • references

  • 25643072